{"id":10,"date":"2018-08-02T11:51:31","date_gmt":"2018-08-02T18:51:31","guid":{"rendered":"https:\/\/vendor.hub.wp.nau.edu\/term\/research\/"},"modified":"2018-10-17T23:28:12","modified_gmt":"2018-10-17T23:28:12","slug":"research","status":"publish","type":"page","link":"https:\/\/in.nau.edu\/term\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Research<\/h1>\n

Biomaterial development<\/h2>\n\n
\n \n\n \n \n <\/span>\n <\/span>\n\n <\/div>\n\n

In the TERM lab, we develop, modify, and evaluate various biomaterials.\u00a0 In the above image are a few examples of our biomaterials efforts.\u00a0 Starting from the left image, a hernia patch (polypropylene mesh) is shown that has been surfaced modified with an extracellular matrix to help minimize inflammation.\u00a0\u00a0Next, an electrospun tropoelastin scaffold is illustrated, for use in the\u00a0development of a wound healing device.\u00a0 To the right,\u00a0a cardiac patch technology is shown, that has been implanted onto an acutely infarcted left ventricle.\u00a0 Notice the new small microvasculature that has developed within the patch after 2 weeks of\u00a0implantation.\u00a0 Lastly, the\u00a0far right image\u00a0demonstrates a double-labeled immunohistochemistry sample from a co-cultured cardiac patch where the blue\u00a0vimentin-reacted fibroblasts are\u00a0co-localized with\u00a0the red troponin-reacted cardiomyocytes.<\/p>\n

Bioengineering replacement skin<\/h2>\n

\"SEM<\/h3>\n

(Left image)<\/em><\/strong> Native decellularized (without cells) skin with a 59% porous architecture.
\n(Right image)<\/strong> Bioengineered replacement skin, electrospun using skin proteins for wound healing applications with a 59% porous architecture.\u00a0 This research is being performed by NAU undergraduate Jordan Muller and Ph.D. graduate student Robert Diller in Dr. Robert Kellar’s TERM laboratory.<\/em><\/p>\n

Biomaterial activation of platelet-rich plasma for wound healing applications<\/strong><\/h2>\n

\"Tabor<\/p>\n

(From left to right):<\/strong> Far left is an SEM image depicting whole blood containing erythrocyte(s) and an inactive platelet. Middle image contains platelets activated with a collagen scaffold. Far right is a highly magnified image showing platelet vesicular release. These images were created by Aaron J \u00a0Tabor, Ph.D., in the TERM laboratory of Dr. Robert Kellar.<\/em><\/p>\n

Bench top (in vitro<\/em>) wound healing assay<\/h2>\n\n
\n \n\n \n \n <\/span>\n <\/span>\n\n <\/div>\n\n

(100x) The above image demonstrates an in vitro \u201cwound healing\u201d scratch assay that was developed in the TERM laboratory by Bronson Pinto (Bioengineering Ph.D. Graduate Student). The scratch assay has been used in the lab as an early study tool to evaluate the effects of both soluble and insoluble compounds on wound closure (e.g. dermal fibroblast migration and proliferation). The assay allows for accurate, cost effective and high throughput experimentation. The starting wound width is shown in the far left image and closes over time (from left to right).<\/em><\/p>\n

Culture of isolated white and brown adipose-derived stem cell<\/h3>\n

\"research
\nStem cells were isolated from brown adipose tissue (BAT) and white adipose tissue (WAT), cultured, and examined at two day time points using an inverted microscope. The following images show the difference in growth between BAT and WAT derived stem cells.
\n(Top images, from left to right)<\/strong>: Brown adipose-derived stem cells at day 4, 6, and 8.
\n(Bottom images, from left to right)<\/strong>: White adipose-derived stem cells at day 4, 6, and 8. WAT stem cells reached confluence one week post-isolation, while BAT stem cells reached approximately 40% confluence. This research was performed by Martha Fowler (NAU Biology M.S. Student).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Research Biomaterial development In the TERM lab, we develop, modify, and evaluate various biomaterials.\u00a0 In the above image are a few examples of our biomaterials efforts.\u00a0 Starting from the left image, a hernia patch (polypropylene mesh) is shown that has been surfaced modified with an extracellular matrix to help minimize inflammation.\u00a0\u00a0Next, an electrospun tropoelastin scaffold […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","ring_central_script_selection":"","footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":0,"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"wp:attachment":[{"href":"https:\/\/in.nau.edu\/term\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}