{"id":314,"date":"2023-04-24T22:29:20","date_gmt":"2023-04-24T22:29:20","guid":{"rendered":"https:\/\/nau.edu\/research\/?page_id=314"},"modified":"2024-12-12T17:32:49","modified_gmt":"2024-12-12T17:32:49","slug":"c-difficile-infection","status":"publish","type":"page","link":"https:\/\/in.nau.edu\/research\/innovations\/available-technologies\/biomedical\/c-difficile-infection\/","title":{"rendered":"Targeted Therapeutic for Human C. Difficile Infection"},"content":{"rendered":"<div class=\"nau-block nau-block-left-nav-top-bound\">\n    \t<button id=\"left-nav-toggle-btn\" onclick=\"toggleNav();\">\n\t\tON THIS PAGE \n\t\t<i id=\"chevron-icon\" class=\"fas fa-solid fa-chevron-down\"><\/i>\n\t<\/button>\n\t<div id=\"left-nav-menu-track\">\n\t\t<div id=\"left-nav-wrapper\">\n\t\t\t<div class=\"rfi-above-anchor-tags\">\n\t\t\t\t<div class=\"ri-container\">\n\t\t\t\t\t<a href=\"https:\/\/nau.edu\/admissions\/request-information\/\" id=\"request-info\" class=\"btn bg-true-blue left-nav-menu-bottom-button display-mobile\">Request info&nbsp;&nbsp;<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div id=\"left-nav-menu\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"menu-section backcolor\">\n\t\t\t\t\t<div class=\"header\">\n\t\t\t\t\t\tHOW CAN WE HELP?\t\t\t\t\t<\/div>\n\t\t\t\t\t<ul class=\"responsive-icons\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"tel:928-523-4620\"><img decoding=\"async\" src=\"https:\/\/in.nau.edu\/wp-content\/themes\/nau-marketing-2021\/img\/icon-phone.svg\" alt=\"Telephone:\"> 928-523-4620<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"mailto:nauinnovations@nau.edu\"><img decoding=\"async\" src=\"https:\/\/in.nau.edu\/wp-content\/themes\/nau-marketing-2021\/img\/icon-email.svg\" alt=\"Email:\"><span class=\"left-nav-email\"> nauinnovations&#8203;@nau.edu <\/span><\/a><\/li>\n\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<section class=\"nau-block left-nav-section\"><header class=\"entry-header\"><div class=\"breadcrumb\"><ol class=\"breadcrumbs\"><li><a href=\"https:\/\/in.nau.edu\">IN<\/a><span class=\"breadcrumb-chevron\" aria-hidden=\"true\">&gt;<\/span><\/li><li><a href=\"https:\/\/in.nau.edu\/research\">Research<\/a><span class=\"breadcrumb-chevron\" aria-hidden=\"true\">&gt;<\/span><\/li><li class=\"current\">Pages<\/li><\/ol><\/div><h1 class=\"entry-title text-left \">Targeted Therapeutic for Human C. Difficile Infection<\/h1><hr class=\"h1-hr  text-left \" role=\"none\"><\/header><!-- .entry-header --><\/section><!-- <section class=\"nau-block left-nav-section grid-md-12\">\n    <header class=\"entry-header\">\n        <h1 class=\"entry-title text-left \" tabindex=\"0\" id=\"h1-first\">Dummy H1<\/h1>\n        <hr class=\"h1-hr  text-left \" role=\"none\">\n    <\/header>\n<\/section> -->\n\n<section class=\"nau-block left-nav-section grid-md-12\">\n    <div class=\"page-content\">\n        \n\n<h2 class=\"wp-block-heading\">Description<\/h2>\n\n\n\n<p>Marked by an increase in disease severity and recurrence since the early 2000s,&nbsp;<em>Clostridioides difficile<\/em>&nbsp;(Clostridium) infection (CDI) has rapidly become an emerging public health threat. Recent research in canines has explored the mechanisms and interactions responsible for resistance to&nbsp;<em>C. difficile<\/em>&nbsp;colonization in the healthy human gut and characterized the underlying bacterial communities responsible for this phenotype. These findings support asymptomatic carriage in canines and suggest features of the gut microbiome and\/or a canine-specific immune response that protects against CDI. Two biologically relevant bacteria in the canine samples were identified that may aid in&nbsp;<em>C. difficile<\/em>&nbsp;resistance, which may be associated with regulating homeostasis in the canine gut.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Additional information<\/h2>\n\n\n\n<section  \n    class=\"nau-block nau-block-panels   \" \n    data-layout_mobile=\"groupLayout-Stack gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_tablet=\"groupLayout-Stack gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_desktop=\"groupLayout-Tabs gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_xl=\"groupLayout-Tabs gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\">\n\n    <div class=\"background-wrapper\">\n        <div class=\"block-main-content\">\n            \n            \n                            <div class=\"tab-nav\" role=\"tablist\" aria-label=\"Tabs for  articles\">\n                                                \n                        <button data-panel=\"panel--0\"\n                            role=\"tab\"\n                            aria-controls=\"panel--0\"\n                            class=\"active bg-true-blue bg-none\"\n                            tabindex=\"0\">Patent number and inventor<\/button>\n                                                \n                        <button data-panel=\"panel--1\"\n                            role=\"tab\"\n                            aria-controls=\"panel--1\"\n                            class=\"after-active bg-true-blue bg-none\"\n                            tabindex=\"-1\">Potential applications<\/button>\n                                                \n                        <button data-panel=\"panel--2\"\n                            role=\"tab\"\n                            aria-controls=\"panel--2\"\n                            class=\" bg-true-blue bg-none\"\n                            tabindex=\"-1\">Benefits and advantages<\/button>\n                                                \n                        <button data-panel=\"panel--3\"\n                            role=\"tab\"\n                            aria-controls=\"panel--3\"\n                            class=\" bg-true-blue bg-none\"\n                            tabindex=\"-1\">Case number and licensing status<\/button>\n                                    <\/div>\n            \n            \n            \n            <div class=\"panel-wrapper\">\n                \n                                \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--0\"\n                            id=\"panel--0\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Patent number and inventor<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>16\/562,378<\/p>\n<p>Nathan Stone, David Wagner, Joseph Busch, Emily Cope, Paul Keim, Fernando Monroy, and Jason Sahl.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--1\"\n                            id=\"panel--1\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Potential applications<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>Clinical applications to provide\u00a0<em>C. difficile<\/em>\u00a0resistance.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--2\"\n                            id=\"panel--2\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Benefits and advantages<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>This research suggests that canines may be hidden reservoirs for\u00a0<em>C. difficile<\/em>\u00a0and that the mechanisms of CDI resistance in the canine gut could provide insights into targeted therapeutics for human CDI.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--3\"\n                            id=\"panel--3\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Case number and licensing status<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>2019-002<\/p>\n<p>This invention is available for licensing.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                                                <\/div>\n\n                    <\/div>\n    <\/div>\n<\/section>\n\n    <\/div>\n<\/section>\n\n<div class=\"nau-block nau-block-left-nav-bottom-bound\">\n\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":276,"featured_media":1037,"parent":65,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","ring_central_script_selection":"","footnotes":""},"class_list":["post-314","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/users\/276"}],"replies":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/comments?post=314"}],"version-history":[{"count":13,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/314\/revisions"}],"predecessor-version":[{"id":6105,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/314\/revisions\/6105"}],"up":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/65"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/media\/1037"}],"wp:attachment":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/media?parent=314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}