{"id":312,"date":"2023-04-24T22:28:03","date_gmt":"2023-04-24T22:28:03","guid":{"rendered":"https:\/\/nau.edu\/research\/?page_id=312"},"modified":"2024-12-12T16:24:28","modified_gmt":"2024-12-12T16:24:28","slug":"hearing-loss","status":"publish","type":"page","link":"https:\/\/in.nau.edu\/research\/innovations\/available-technologies\/biomedical\/hearing-loss\/","title":{"rendered":"Oligonucleotide Protection and Treatment of Hearing Loss"},"content":{"rendered":"<div class=\"nau-block nau-block-left-nav-top-bound\">\n    \t<button id=\"left-nav-toggle-btn\" onclick=\"toggleNav();\">\n\t\tON THIS PAGE \n\t\t<i id=\"chevron-icon\" class=\"fas fa-solid fa-chevron-down\"><\/i>\n\t<\/button>\n\t<div id=\"left-nav-menu-track\">\n\t\t<div id=\"left-nav-wrapper\">\n\t\t\t<div class=\"rfi-above-anchor-tags\">\n\t\t\t\t<div class=\"ri-container\">\n\t\t\t\t\t<a href=\"https:\/\/nau.edu\/admissions\/request-information\/\" id=\"request-info\" class=\"btn bg-true-blue left-nav-menu-bottom-button display-mobile\">Request info&nbsp;&nbsp;<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div id=\"left-nav-menu\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"menu-section backcolor\">\n\t\t\t\t\t<div class=\"header\">\n\t\t\t\t\t\tHOW CAN WE HELP?\t\t\t\t\t<\/div>\n\t\t\t\t\t<ul class=\"responsive-icons\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"tel:928-523-4620\"><img decoding=\"async\" src=\"https:\/\/in.nau.edu\/wp-content\/themes\/nau-marketing-2021\/img\/icon-phone.svg\" alt=\"Telephone:\"> 928-523-4620<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"mailto:nauinnovations@nau.edu\"><img decoding=\"async\" src=\"https:\/\/in.nau.edu\/wp-content\/themes\/nau-marketing-2021\/img\/icon-email.svg\" alt=\"Email:\"><span class=\"left-nav-email\"> nauinnovations&#8203;@nau.edu <\/span><\/a><\/li>\n\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<section class=\"nau-block left-nav-section\"><header class=\"entry-header\"><div class=\"breadcrumb\"><ol class=\"breadcrumbs\"><li><a href=\"https:\/\/in.nau.edu\">IN<\/a><span class=\"breadcrumb-chevron\" aria-hidden=\"true\">&gt;<\/span><\/li><li><a href=\"https:\/\/in.nau.edu\/research\">Research<\/a><span class=\"breadcrumb-chevron\" aria-hidden=\"true\">&gt;<\/span><\/li><li class=\"current\">Pages<\/li><\/ol><\/div><h1 class=\"entry-title text-left \">Oligonucleotide Protection and Treatment of Hearing Loss<\/h1><hr class=\"h1-hr  text-left \" role=\"none\"><\/header><!-- .entry-header --><\/section><!-- <section class=\"nau-block left-nav-section grid-md-12\">\n    <header class=\"entry-header\">\n        <h1 class=\"entry-title text-left \" tabindex=\"0\" id=\"h1-first\">Dummy H1<\/h1>\n        <hr class=\"h1-hr  text-left \" role=\"none\">\n    <\/header>\n<\/section> -->\n\n<section class=\"nau-block left-nav-section grid-md-12\">\n    <div class=\"page-content\">\n        \n\n<h2 class=\"wp-block-heading\">Description<\/h2>\n\n\n\n<p>Currently, there are no widely acceptable medications to prevent hearing loss or increase the ability of the ear to recover from injury. This technology employs a tandem sequence of oligonucleotides (called t-oligo) with homology to mammalian telomere chromosome sequence to prevent hearing loss from noise injury. The basis for this auditory protection is related to protective DNA repair enzymes that respond in the presence of t-oligo. T-oligo are strings of DNA with the sequence TTAGGG and are known to increase DNA repair capacity that protects cells from injury by increasing their capacity to repair themselves. However, this oligonucleotide has not been used to protect hearing, and this invention provides a novel use of t-oligo to preserve hearing following noise injury.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Additional information<\/h2>\n\n\n\n<section  \n    class=\"nau-block nau-block-panels   \" \n    data-layout_mobile=\"groupLayout-Stack gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_tablet=\"groupLayout-Stack gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_desktop=\"groupLayout-Tabs gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\"\n        data-layout_xl=\"groupLayout-Tabs gutter_Default panelLayoutPhotoTextVertical  photoAspect-1-1\">\n\n    <div class=\"background-wrapper\">\n        <div class=\"block-main-content\">\n            \n            \n                            <div class=\"tab-nav\" role=\"tablist\" aria-label=\"Tabs for  articles\">\n                                                \n                        <button data-panel=\"panel--0\"\n                            role=\"tab\"\n                            aria-controls=\"panel--0\"\n                            class=\"active bg-true-blue bg-none\"\n                            tabindex=\"0\">Patent number and inventor<\/button>\n                                                \n                        <button data-panel=\"panel--1\"\n                            role=\"tab\"\n                            aria-controls=\"panel--1\"\n                            class=\"after-active bg-true-blue bg-none\"\n                            tabindex=\"-1\">Potential applications<\/button>\n                                                \n                        <button data-panel=\"panel--2\"\n                            role=\"tab\"\n                            aria-controls=\"panel--2\"\n                            class=\" bg-true-blue bg-none\"\n                            tabindex=\"-1\">Benefits and advantages<\/button>\n                                                \n                        <button data-panel=\"panel--3\"\n                            role=\"tab\"\n                            aria-controls=\"panel--3\"\n                            class=\" bg-true-blue bg-none\"\n                            tabindex=\"-1\">Case number and licensing status<\/button>\n                                    <\/div>\n            \n            \n            \n            <div class=\"panel-wrapper\">\n                \n                                \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--0\"\n                            id=\"panel--0\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Patent number and inventor<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>9,457,009 and 10,124,062<\/p>\n<p>O\u2019neil Guthrie<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--1\"\n                            id=\"panel--1\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Potential applications<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>Hearing loss and protection against noise trauma.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--2\"\n                            id=\"panel--2\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Benefits and advantages<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>This technology focuses on DNA repair associated with the regeneration of cochlear function after injury and suggests that inducible DNA repair enzymes exist in the mammalian cochlea, and that these enzymes could be therapeutically optimized.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                    \n                        <div class=\"panel bg-true-blue  panelTypeText  noHover \"\n                            data-role=\"tabpanel\"\n                            data-panel=\"panel--3\"\n                            id=\"panel--3\">\n\n                            \n                                                                    <div class=\"content\">\n                                            <div class=\"text-wrapper\">\n                                                                                                <h3 class=\"h3-tab-index\">Case number and licensing status<\/h3>\n                                                \n                                                                                                    <div class=\"text\">\n                                                        <p>2015-021<\/p>\n<p>This invention is licensed, with a potential interest in partnerships.<\/p>\n                                                    <\/div>\n                                                \n                                                                                            <\/div>\n                                        <\/div>\n\n                                    \n                                \n                                                        <\/div>\n                                                <\/div>\n\n                    <\/div>\n    <\/div>\n<\/section>\n\n    <\/div>\n<\/section>\n\n<div class=\"nau-block nau-block-left-nav-bottom-bound\">\n\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":276,"featured_media":1037,"parent":65,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","ring_central_script_selection":"","footnotes":""},"class_list":["post-312","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/users\/276"}],"replies":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/comments?post=312"}],"version-history":[{"count":17,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/312\/revisions"}],"predecessor-version":[{"id":6064,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/312\/revisions\/6064"}],"up":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/pages\/65"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/media\/1037"}],"wp:attachment":[{"href":"https:\/\/in.nau.edu\/research\/wp-json\/wp\/v2\/media?parent=312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}