{"id":65897,"date":"2022-04-14T08:55:13","date_gmt":"2022-04-14T15:55:13","guid":{"rendered":"https:\/\/in.nau.edu\/news\/?p=65897"},"modified":"2022-04-14T08:55:13","modified_gmt":"2022-04-14T15:55:13","slug":"valley-fever-collaborative","status":"publish","type":"post","link":"https:\/\/in.nau.edu\/news\/valley-fever-collaborative\/","title":{"rendered":"NAU researchers part of statewide Valley Fever Collaborative awarded $3M in research funds"},"content":{"rendered":"<p><strong>\u00a0<\/strong>The Valley Fever Collaborative, a University of Arizona Health Sciences-led partnership with Northern Arizona University and Arizona State University, was awarded $3.1 million in funding by the Arizona Board of Regents to start an integrated, statewide research project to identify, characterize and map hotspots and routes of exposure for Valley fever, an important public health and economic problem in the Southwest.<\/p>\n<p>This three-year collaborative includes multiple researchers in NAU\u2019s <a href=\"https:\/\/in.nau.edu\/pmi\/\">Pathogen and Microbiome Institute<\/a> (PMI).<\/p>\n<p>Valley fever is an infectious disease that affects thousands of people in Arizona every year. It is caused by <em>Coccidioides posadasii<\/em>, a fungus that lives in the soil of areas with hot summers, mild winters and little rainfall, which includes much of Arizona. The fungal spores can be readily inhaled, which is how most Valley fever infections are believed to occur. Yet the amount of fungal burden in the soil and air, the degree to which these fungal spores travel, and the potential for new areas to be colonized with the organism are currently unknown.<\/p>\n<p>\u201cWe know Arizona is responsible for two-thirds of all U.S. Valley fever infections, but just looking across the land we can\u2019t tell which places the fungus grows or are the source of so many infections,\u201d said Dr. John Galgiani, director of the Valley Fever Center for Excellence in the University of Arizona College of Medicine-Tucson and a member of the BIO5 Institute. \u201cThis study will try to connect the dots between strains that cause people to get sick, where in the land they come from and what it is about those hot spots that makes the fungus thrive. With this new information, we might prevent infections at work sites or even for everyone who lives here.\u201d<\/p>\n<p>This collaboration is critical in directly addressing the threat that Valley fever poses to all of Arizona, said <strong>Paul Keim<\/strong>, Regents\u2019 professor of biology and executive director of PMI.<\/p>\n<p>\u201cThe ABOR funding will accelerate the coordination of expertise at all three universities to understand and then attack\u00a0Valley\u00a0fever\u2019s public health impact,\u201d he said. \u201cThis is an amazing cross-disciplinary project that would be difficult to fund from other sources. Arizona can expect tangible benefits that improve the health and lives of our citizens.\u201d<\/p>\n<p>Six individual projects will take place using funding provided through Arizona\u2019s Technology and Research Initiative Fund. They are:<\/p>\n<ul>\n<li><strong>Detection of <em>Coccidioides<\/em> from air sampled at positive soil locations<\/strong><br \/>\n<strong>Bridget Barker<\/strong>, an associate professor in the Department of Biological Sciences at NAU, will lead a team of researchers who pair air-sampling devices with soil sampling at three statewide sites to detect seasonal patterns of Valley fever risk. The goal is to develop risk assessment models to guide land developers, agriculture and state planners. Barker is one of the leading Valley fever researchers in Arizona.<\/li>\n<li><strong>Genome analysis directly from the environment<\/strong><br \/>\n<strong>David Wagner<\/strong>, professor in the Department of Biological Sciences at NAU, and Keim will establish a genomic database of environmental <em> posadasii<\/em>, which can be used to better understand and predictively model the environmental sources of Valley fever in Arizonans.<\/li>\n<li><strong>Toward a predictive model of <em>Coccidioides<\/em> hot spots and hot moments on the Arizona landscape: characteristics and dynamics of soils harboring Valley fever<br \/>\n<\/strong>Led by Jon Chorover, professor and head of the Department of Environmental Science at the University of Arizona College of Agriculture and Life Sciences, researchers will combine soil sampling and laboratory geochemical, mineralogical and physical analyses with sensor array data from research sites. The goals are to identify soil characteristics most frequently associated with high prevalence of <em>Coccidioides<\/em> spores and determine the soil and ambient atmospheric conditions that promote the aerosolized suspension and movement of <em>Coccidioides<\/em> spores from those locations.<\/li>\n<li><strong>Identifying Valley fever hotspots from genetic clusters in patient specimens<\/strong><br \/>\nGalgiani will lead a team of researchers seeking to determine to what degree Valley fever human infections are due to hotspots in the environment in Arizona by investigating genetically coccidioidal isolates from infected patients in relation to environmental sequences and identifying genetic clusters.<\/li>\n<li><strong>Environmental detection, modeling, and genomics of Valley fever in Arizona<\/strong><br \/>\nMatthew Fraser, a professor in the School of Sustainable Engineering and Built Environment at ASU, and Pierre Herckes, a professor in the School of Molecular Sciences at ASU, will lead a project to collect and analyze particles in the air at locations near Valley fever hotspots to determine the physical and biological characteristics of particles and understand the nature of airborne transmission.<\/li>\n<li><strong>Geospatial modeling and visualization of diverse Valley fever data<br \/>\n<\/strong>Jon Miller, director of the Decision Theater at ASU, and Sean Dudley, assistant vice president and chief research information officer at ASU, will develop a geospatial analysis platform to be used for predictive modeling and decision support.<\/li>\n<\/ul>\n<p>&#8220;I\u2019m really excited about working with this diverse interdisciplinary team as we will get to address this important problem from multiple angles simultaneously,&#8221; Wagner said. &#8220;In particular, I can\u2019t wait to apply DNA enrichment techniques to Valley fever. We\u2019ve had great success with this approach with other pathogens, and I think it could be a real game changer for Valley fever research.&#8221;<\/p>\n<p>Barker agreed.<\/p>\n<p>&#8220;It\u2019s a wonderful opportunity to bring many skills to the table to tackle this fungus,&#8221; she said. &#8220;The organism grows in desert soil, and disease\/infection is acquired from the environment, but we understand so little about the ecology of the organism.&#8221;<\/p>\n<p>\u201cOur goal is to address the problem of\u00a0Valley\u00a0fever at its source, in the soil and air we breathe,\u201d said Neal Woodbury, vice president for research and chief science and technology officer for ASU\u2019s Knowledge Enterprise. \u201cBy understanding where the fungal pathogen grows and how it enters the air, we can pinpoint approaches to avoid human exposure to begin with.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p><a class=\"search-results-excerpt-link\" href=\"https:\/\/in.nau.edu\/news\/valley-fever-collaborative\/\">\u00a0The Valley Fever Collaborative, a University of Arizona Health Sciences-led partnership with Northern Arizona University and Arizona State University, was awarded $3.1 million in funding by the Arizona Board of Regents to start an integrated, statewide research project to identify, characterize and map hotspots and routes of exposure for Valley fever, an important public health&hellip;<\/a><\/p>\n","protected":false},"author":59,"featured_media":65898,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[],"class_list":["post-65897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-academics"],"acf":[],"_links":{"self":[{"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/posts\/65897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/comments?post=65897"}],"version-history":[{"count":0,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/posts\/65897\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/media\/65898"}],"wp:attachment":[{"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/media?parent=65897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/categories?post=65897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/in.nau.edu\/news\/wp-json\/wp\/v2\/tags?post=65897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}