{"id":6,"date":"2018-08-20T08:13:13","date_gmt":"2018-08-20T15:13:13","guid":{"rendered":"https:\/\/vendor.hub.wp.nau.edu\/cell-molecular-pathology\/biomedicine-discovery-program\/"},"modified":"2018-08-21T14:59:29","modified_gmt":"2018-08-21T21:59:29","slug":"biomedicine-discovery-program","status":"publish","type":"page","link":"https:\/\/in.nau.edu\/cell-molecular-pathology\/biomedicine-discovery-program\/","title":{"rendered":"Biomedicine discovery program"},"content":{"rendered":"<h1>Biomedicine discovery program<\/h1>\n<p>The CMPL is interested in developing biomedical approaches to prevent or treat intractable conditions such as hearing loss.\u00a0 Therefore, two independent approaches are currently under research and development.\u00a0 The newest approach is based on the engineering of specific molecular constructs that will increase the capacity of cells to repair themselves after injury (further information is restricted at this time).\u00a0 The other approach\u00a0 employs specific low molecular weight chemotypes called carboxy alkyl esters (CAEs) to enhance recovery of sensory and neural functions following injury. This research is important because it suggests (for the first time) that CAEs may be used as a novel approach to prevent or treat hearing loss. The goals of this line of research are to 1) determine the underlying molecular mechanisms that facilitate cellular repair, 2) optimize the treatment regimen to achieve maximal repair, 3) identify other molecules that have the capacity to augment cellular repair, and 4) conduct clinical trials to determine efficacy among patients.<\/p>\n<p><u>What are CAEs and how do they work?<\/u>\u00a0 CAEs are phytochemicals found in healthy foods and beverages such as fruits, vegetables, coffee and tea.\u00a0 They provide direct trophic support to cells.\u00a0 However, they can function through systemic metabolism.\u00a0 For instance, CAEs are involved in systemic biochemical reactions that increase bioavailability of essential nutrients.\u00a0 One proposed reaction that is currently under investigation is illustrated.<\/p>\n<!-- shortcode-image-block -->\n<div class=\"shortcode-image-block\">\n                <!-- shortcode-image-caption -->\n<span class=\"shortcode-image-caption shortcode-image-caption--left\">\n        <span class=\"shortcode-image-caption__container\">\n                <img src='\/wp-content\/uploads\/sites\/64\/2018\/08\/Biomedicine-ek.png' srcset='' sizes='' \/>\n    <\/span>\n    <\/span>\n\n          <\/div>\n\n<p>A) The metabolism of a CAE by enteric microbiota increases host DNA repair capacity, antioxidation, NAD\/ATP synthesis and regulates inflammation and immune responses.\u00a0 B) Production of aromatic amino acids (Trp, Phe and Tyr) by the shikimate biosynthetic pathway of the gastrointestinal microflora.\u00a0 Abbreviations:\u00a0 NAD, nicotinamine adenine dinucleotide; ATP, adenosine triphosphate; 2Pi, two-inorganic phosphates; PEP, phosphoenolpyruvate; Trp, tryptophan; Phe, Phenylalanine; Tyr, tyrosine.<\/p>\n<p><!--script class=\"ektron-script\"&gt;         if ($(\".catalog_script_placeholder\")[0]) {             var scriptsLoaded = 0;             $.getScript( \"\/\/catalog.nau.edu\/Catalog\/resources\/js\/jquery.catalogFrames.js\").done(function() {                 $.getScript( \"\/\/catalog.nau.edu\/Catalog\/resources\/js\/easyXDM.min.js\").done(function() {                     var placeholder = $(\".catalog_script_placeholder\");                     var divId = placeholder.attr('divId');                     var Program = placeholder.attr('Program');                     var catalogFrameDisplayData = {};                     catalogFrameDisplayData[placeholder.attr('DisplayType')] = true;                     var catalogFrameData = {};                     catalogFrameData[\"display\"] = catalogFrameDisplayData;                     catalogFrameData[\"url\"] = \"https:\/\/catalog.nau.edu\"; 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